Retrocyclin 2 : a new therapy against avian influenza H5N1 virus in vivo and vitro

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dc.contributor.authorQing-long Liang
dc.contributor.authorKai Zhou
dc.contributor.authorHong-xuan He
dc.date.accessioned2012-08-29T19:13:25Z
dc.date.available2012-08-29T19:13:25Z
dc.date.issued2010
dc.description.abstractWe tested the ability of retrocyclin 2, a type of h defensin, to protect cells and chicken embryos from infection by H5N1 highly pathogenic avian influenza virus. A gene fragment of retrocyclin 2 was designed based on the protein sequence of retrocyclin 2 and cloned into the eukaryotic expression vector pcDNA4.01 (HismaxA), named pcDNA4-RC2. The expression vector pcDNA4-RC2 protected MDCK cells and chicken embryos from infection by the H5N1 virus through inhibition of virus replication and viral mRNA transcription. Retrocyclin 2 is therefore effective in preventing H5N1 virus infection in vivo and in vitro and could be considered as a new therapy for H5N1 influenza and other diseases.en
dc.formatTexten
dc.format.extent1 digital file (p. 387-392)en
dc.format.mimetypeApplication/pdf
dc.identifier.citationQing-long Liang, Kai Zhou, & Hong-xuan He (2010). Retrocyclin 2: a new therapy against avian influenza H5N1 virus in vivo and vitro. Biotechnol Lett, 32, 387-392. doi:10.1007/s10529-009-0167-2en
dc.identifier.urihttp://hdl.handle.net/10625/50228
dc.language.isoen
dc.publisherSpringeren
dc.relation.journalBiotechnol Lett
dc.subjectAVIAN INFLUENZA VIRUSen
dc.subjectCHICKEN EMBRYOSen
dc.subjectH5N1en
dc.subjectINFLUENZA VIRUSen
dc.subjectMDCK CELLSen
dc.subjectRETROCYCLIN 2en
dc.subjectINFLUENZA IN BIRDSen
dc.subjectINFLUENZA A VIRUS, H5N1 SUBTYPEen
dc.titleRetrocyclin 2 : a new therapy against avian influenza H5N1 virus in vivo and vitroen
dc.typeJournal Article (peer-reviewed)en
idrc.copyright.holderSpringer Science+Business Media B.V.
idrc.dspace.accessIDRC Onlyen
idrc.noaccessDue to copyright restrictions the full text of this research output is not available in the IDRC Digital Library or by request from the IDRC Library. / Compte tenu des restrictions relatives au droit d'auteur, le texte intégral de cet extrant de recherche n'est pas accessible dans la Bibliothèque numérique du CRDI, et il n'est pas possible d'en faire la demande à la Bibliothéque du CRDI.en
idrc.project.number103190
idrc.project.titleAvian Influenza in Migratory Birds : Regional Surveillance and Monitoring Networken
idrc.rims.adhocgroupIDRC SUPPORTEDen

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2010-2019 / Années 2010-2019
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