Analysis of human infectious avian influenza virus : hemagglutinin genetic characteristics in Asia and Africa from 2004 to 2009
| dc.contributor.author | Jirong Zhang | |
| dc.contributor.author | Fumin Lei | |
| dc.date.accessioned | 2012-08-29T16:54:41Z | |
| dc.date.available | 2012-08-29T16:54:41Z | |
| dc.date.issued | 2010 | |
| dc.description.abstract | In the present study, we used nucleotide and protein sequences of avian influenza virus H5N1, which were obtained in Asia and Africa, analyzed HA proteins using ClustalX1.83 and MEGA4.0, and built a genetic evolutionary tree of HA nucleotides. The analysis revealed that the receptor specificity amino acid of A/HK/213/2003, A/Turkey/65596/2006 and etc mutated into QNG, which could bind with á-2, 3 galactose and á-2, 6 galactose. A mutation might thus take place and lead to an outbreak of human infections of avian influenza virus. The mutations of HA protein amino acids from 2004 to 2009 coincided with human infections provided by the World Health Organization, indicating a “low–high–highest–high–low” pattern. We also found out that virus strains in Asia are from different origins: strains from Southeast Asia and East Asia are of the same origin, whereas those from West Asia, South Asia and Africa descend from one ancestor. The composition of the phylogenetic tree and mutations of key site amino acids in HA proteins reflected the fact that the majority of strains are regional and long term, and virus diffusions exist between China, Laos, Malaysia, Indonesia, Azerbaijan, Turkey and Iraq. We would advise that pertinent vaccines be developed and due attention be paid to the spread of viruses between neighboring countries and the dangers of virus mutation and evolution. | en |
| dc.format | Text | en |
| dc.format.extent | 1 digital file (p. 264-271) | en |
| dc.format.mimetype | Application/pdf | |
| dc.identifier.citation | Jirong Zhang, & Fumin Lei (2010). Analysis of human infectious avian influenza virus : Hemagglutinin genetic characteristics in Asia and Africa from 2004 to 2009. Integrative Zoology, 5, 264-271.doi:10.1111/j.1749-4877.2010.00212.x | en |
| dc.identifier.uri | http://hdl.handle.net/10625/50225 | |
| dc.language.iso | en | |
| dc.publisher | Blackwell | en |
| dc.relation.journal | Integrative Zoology | |
| dc.subject | AMINO ACID MUTATION | en |
| dc.subject | AVIAN INFLUENZA H5N1 | en |
| dc.subject | EVOLVE | en |
| dc.subject | HEMAGGLUTININ | en |
| dc.subject | INFLUENZA IN BIRDS | en |
| dc.subject | INFLUENZA A VIRUS, H5N1 SUBTYPE | en |
| dc.subject | MUTATIONS | en |
| dc.subject | ZOONOTIC DISEASES | en |
| dc.title | Analysis of human infectious avian influenza virus : hemagglutinin genetic characteristics in Asia and Africa from 2004 to 2009 | en |
| dc.type | Journal Article (peer-reviewed) | en |
| idrc.copyright.holder | ISZS, Blackwell Publishing and IOZ/CAS | |
| idrc.dspace.access | IDRC Only | en |
| idrc.noaccess | Due to copyright restrictions the full text of this research output is not available in the IDRC Digital Library or by request from the IDRC Library. / Compte tenu des restrictions relatives au droit d'auteur, le texte intégral de cet extrant de recherche n'est pas accessible dans la Bibliothèque numérique du CRDI, et il n'est pas possible d'en faire la demande à la Bibliothéque du CRDI. | en |
| idrc.project.number | 103190 | |
| idrc.project.title | Avian Influenza in Migratory Birds : Regional Surveillance and Monitoring Network | en |
| idrc.rims.adhocgroup | IDRC SUPPORTED | en |