Low-dose penicillin in early life induces long-term changes in murine gut microbiota, brain cytokines and behavior

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dc.contributor.authorLeclercq, Sophie
dc.contributor.authorMian, Firoz M.
dc.contributor.authorStanisz, Andrew M.
dc.contributor.authorBindels, Laure B.
dc.contributor.authorCambier, Emmanuel
dc.contributor.authorBen-Amram, Hila
dc.contributor.authorKoren, Omry
dc.contributor.authorForsythe, Paul
dc.contributor.authorBienenstock, John
dc.date.accessioned2019-01-28T20:53:08Z
dc.date.available2019-01-28T20:53:08Z
dc.date.issued2017-04
dc.descriptionWe acknowledge grant support from the US Office for Naval Research (ONR) (N00014-14-1-0787). S.L. is a recipient of a post-doctoral fellowship from the ONR and received funds from FSR (Fonds Spe´cial de la Recherche), Belgium. P.F. and O.K. are supported by the Canadian-Israel Health Initiative, jointly funded by the Canadian Institutes of Health Research, the Israel Science Foundation, the International Development Research Centre, Canada and the Azrieli Foundation.en
dc.description.abstractThere is increasing concern about potential long-term effects of antibiotics on children’s health. Epidemiological studies have revealed that early-life antibiotic exposure can increase the risk of developing immune and metabolic diseases, and rodent studies have shown that administration of high doses of antibiotics has long-term effects on brain neurochemistry and behaviour. Here we investigate whether low-dose penicillin in late pregnancy and early postnatal life induces long-term effects in the offspring of mice. We find that penicillin has lasting effects in both sexes on gut microbiota, increases cytokine expression in frontal cortex, modifies blood–brain barrier integrity and alters behaviour. The antibiotic-treated mice exhibit impaired anxiety-like and social behaviours, and display aggression. Concurrent supplementation with Lactobacillus rhamnosus JB-1 prevents some of these alterations. These results warrant further studies on the potential role of early-life antibiotic use in the development of neuropsychiatric disorders, and the possible attenuation of these by beneficial bacteria.en
dc.format.mimetypeapplication/pdf
dc.identifier.citationLeclercq, S. et al. Low-dose penicillin in early life induces long-term changes in murine gut microbiota, brain cytokines and behavior. Nat. Commun. 8, 15062 doi: 10.1038/ncomms15062 (2017).en
dc.identifier.urihttp://hdl.handle.net/10625/57450
dc.language.isoen
dc.publisherSpringer Nature - Nature Communicationsen
dc.subjectANTIBIOTICSen
dc.subjectCHILD HEALTHen
dc.subjectPENICILLINen
dc.subjectMICEen
dc.subjectGUT MICROBIOTAen
dc.subjectLACTOBACILLUS RHAMNOSUS JB-1 SUPPLEMENTATIONen
dc.subjectBENEFICIAL BACTERIAen
dc.titleLow-dose penicillin in early life induces long-term changes in murine gut microbiota, brain cytokines and behavioren
dc.typeJournal Article (peer-reviewed)en
idrc.copyright.oapermissionsourceThis work is licensed under a Creative Commons Attribution 4.0 International License.en
idrc.dspace.accessOpen Accessen
idrc.project.number108189
idrc.project.titleEffect of Antibiotics in Early-life on Brain Function and Behaviouren
idrc.recordsserver.bcsnumberIC36-1643402171-216887
idrc.rims.adhocgroupIDRC SUPPORTEDen

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