Motor alterations associated with exposure to manganese in the environment in Mexico

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dc.contributor.authorRodríguez-Agudelo, Yaneth
dc.contributor.authorRiojas-Rodríguez, Horacio
dc.contributor.authorRíos, Camilo
dc.contributor.authorRosas, Irma
dc.contributor.authorSabido Pedraza, Eva
dc.contributor.authorMiranda, Javier
dc.contributor.authorSiebe, Christina
dc.contributor.authorTexcalac, José Luis
dc.contributor.authorSantos-Burgoa, Carlos
dc.date.accessioned2011-09-22T12:47:45Z
dc.date.available2011-09-22T12:47:45Z
dc.date.issued2006
dc.description.abstractOverexposure to manganese (Mn) causes neurotoxicity (a Parkinson-like syndrome) or psychiatric damage (“manganese madness”). Several studies have shown alterations to motor and neural behavior associated with exposure to Mn in the workplace. However, there are few studies on the effects of environmental exposure of whole populations. We studied the risk of motor alterations in people living in a mining district in Mexico. We studied 288 individual people (168 women and 120 men) from eight communities at various distances from manganese extraction or processing facilities in the district of Molango. We measured manganese concentrations in airborne particles, water, soil and crops and evaluated the possible routes of Mn exposure. We also took samples of people's blood and determined their concentrations of Mn and lead (Pb). We used “Esquema de Diagnóstico Neuropsicológico” Ardila and Ostrosky-Solís's neuropsychological battery to evaluate motor functions. Concentrations of Mn in drinking water and maize grain were less than detection limits at most sampling sites. Manganese extractable by DTPA in soils ranged between 6 and 280 mg kg−1 and means were largest close to Mn extraction or processing facilities. Air Mn concentration ranged between 0.003 and 5.86 μg/m3; the mean value was 0.42 μg/m3 and median was 0.10 μg/m3, the average value (geometric mean) resulted to be 0.13 μg/m3. Mean blood manganese concentration was 10.16 μg/l, and geometric mean 9.44 μg/l, ranged between 5.0 and 31.0 μg/l. We found no association between concentrations of Mn in blood and motor tests. There was a statistically significant association between Mn concentrations in air and motor tests that assessed the coordination of two movements (OR 3.69; 95% CI 0.9, 15.13) and position changes in hand movements (OR 3.09; CI 95% 1.07, 8.92). An association with tests evaluating conflictive reactions (task that explores verbal regulations of movements) was also found (OR 2.30; CI 95% 1.00, 5.28). It seems from our results that people living close to the manganese mines and processing plants suffer from an incipient motor deficit, as a result of their inhaling manganese-rich dust.en
dc.formatTexten
dc.format.extent1 digital file (p. 542-556)en
dc.identifier.issn0048-9697
dc.identifier.urihttp://hdl.handle.net/10625/47088
dc.language.isoen
dc.publisherElsevieren
dc.relation.ispartofScience of the total environment, v. 368, 2006en
dc.subjectMANGANESEen
dc.subjectMEXICOen
dc.subjectMININGen
dc.subjectENVIRONMENTAL EXPOSUREen
dc.subjectMOTOR ALTERATIONSen
dc.subjectNEUROTOXICITYen
dc.subjectNEUROBEHAVIOURAL TESTINGen
dc.subjectMOTOR SKILLSen
dc.subjectMOLANGOen
dc.subjectMANGANESE POISOININGen
dc.subjectNEUROBEHAVIOURAL MANIFESTATIONSen
dc.subjectENVIRONMENTAL HEALTHen
dc.titleMotor alterations associated with exposure to manganese in the environment in Mexicoen
dc.typeJournal Article (peer-reviewed)en
idrc.dspace.accessIDRC Onlyen
idrc.project.number100662
idrc.project.titleManganese Exposure in the General Population of a Mining Region (Mexico) - Phase Ien
idrc.rims.adhocgroupIDRC SUPPORTEDen

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IDRC Research Results / Résultats de recherches du CRDI
2000-2009 / Années 2000-2009
Environmental Pollution (includes SMEs and Mining) / Pollution de l’environnement (comprend les PME et l'industrie minière)
Latin America and the Caribbean / Amérique latine et Caraïbes
Research Results (Ecohealth) / Résultats de recherches (Écosanté)