Dengue immunopathogenesis : a crosstalk between host and viral factors leading to disease : part II—DENV infection, adaptive immune responses, and NS1 pathogenesis

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dc.contributor.authorPuerta-Guardo, Henry
dc.contributor.authorBiering, Scott B.
dc.contributor.authorHarris, Eva
dc.contributor.authorPavia-Ruz, Norma
dc.contributor.authorVázquez-Prokopec, Gonzalo
dc.date.accessioned2021-04-26T14:16:56Z
dc.date.available2021-04-26T14:16:56Z
dc.date.issued2020-09-23
dc.descriptionTwo part articleen
dc.description.abstractThis chapter details the interplay between distinct host adaptive immune responses and viral factors that together contribute to the development of the dengue virus (DENV) pathogenesis and severe disease. As Part II, it addresses: the multifactorial immunopathogenic process of DENV infection from the perspective of the pre-existing serotype cross-reactive antibodies; the hyperactivation of DENV infected immune cells (monocytes, mast cells) leading to increased cytokine production; the role of T cell responses; the activation of complement pathways; and the new pathogenic roles of the secreted NS1 of DENV that may act together to occasionally cause severe dengue manifestations.en
dc.description.sponsorshipCanadian Institutes of Health Research
dc.description.sponsorshipFondo Mixto CONACYT-Gobierno del Estado de Yucatan
dc.format.mimetypeapplication/pdf
dc.identifier.isbn978-1-78985-649-1
dc.identifier.urihttp://hdl.handle.net/10625/59929
dc.language.isoen
dc.publisherIntechOpenen
dc.relation.urihttp://hdl.handle.net/10625/59930
dc.subjectDENGUEen
dc.subjectMOSQUITO-BORNE DISEASESen
dc.subjectIMMUNOLOGYen
dc.subjectPATHOGENESISen
dc.subjectDISEASE CONTROLen
dc.subjectEPIDEMIOLOGYen
dc.subjectVACCINESen
dc.subjectARBOVIRUSen
dc.subjectLATIN AMERICAen
dc.subjectGLOBAL SOUTHen
dc.titleDengue immunopathogenesis : a crosstalk between host and viral factors leading to disease : part II—DENV infection, adaptive immune responses, and NS1 pathogenesisen
dc.typeBook Chapteren
idrc.copyright.holder© 2020 The Author(s)
idrc.copyright.oapermissionsourceCC BY 4.0en
idrc.dspace.accessOpen Accessen
idrc.project.componentnumber109071002
idrc.project.number109071
idrc.project.titleEnabling Business and Technologies to Contribute to the Control of Mosquito-Borne Diseases in Latin Americaen
idrc.rims.adhocgroupIDRC SUPPORTEDen

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Dengue immunopathogenesis: a crosstalk between host and viral factors leading to disease. A Crosstalk between Host and Viral Factors Leading to Disease: PART II—DENV Infection, Adaptive Immune Responses, and NS1 Pathogenesis
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