Modelling the effects of adherence to the HIV fusion inhibitor enfuvirtide

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dc.contributor.authorLou, Jie
dc.contributor.authorSmith, Robert J
dc.date.accessioned2012-07-17T18:41:48Z
dc.date.available2012-07-17T18:41:48Z
dc.date.copyright2010
dc.date.issued2010
dc.description.abstractRecently, the first drug in a new class of antiretroviral HIV drugs was approved, the fusion inhibitor enfuvirtide. We develop a mathematical model that describes the binding of the virus to T cells. We model the effect of enfuvirtide upon this process using impulsive differential equations. We find equilibria and determine stability in the case of no therapy and then when therapy is taken with perfect adherence. We determine analytical thresholds for the dosage and dosing intervals to ensure the disease-free equilibrium remains stable. We also explore the effects of partial adherence. Our theoretical results suggest that partial adherence may, at times, be worse than no therapy at all, but at other times may in fact as good as perfect adherence. It follows that patients should be counselled on the importance of adherence to this new antiretroviral drug.en
dc.formatTexten
dc.format.extentp. 1-13 : ill.en
dc.identifier.citationLou, J., & Smith, R. J. (2010). Modelling the effects of adherence to the HIV fusion inhibitor enfuvirtide. Journal of Theoretical Biology, 268 (1): 1-13. doi:10.1016/j.jtbi.2010.09.039en
dc.identifier.issn0022-5193
dc.identifier.urihttp://hdl.handle.net/10625/49798
dc.language.isoen
dc.relation.journalJournal of Theoretical Biology
dc.subjectENFUVIRTIDEen
dc.subjectFUSION INHIBITORSen
dc.subjectANTIRETROVIRAL THERAPYen
dc.subjectMATHEMATICAL MODELSen
dc.subjectADHERENCEen
dc.subjectHIVen
dc.subjectDOSE RESPONSE RELATIONSHIP DRUGen
dc.subjectMEDICATION ADHERENCEen
dc.subjectPATIENT COMPLIANCEen
dc.subjectT-LYMPHOCYTESen
dc.titleModelling the effects of adherence to the HIV fusion inhibitor enfuvirtideen
dc.typeAbstracten
idrc.copyright.holderElsevier
idrc.dspace.accessIDRC Onlyen
idrc.noaccessDue to copyright restrictions the full text of this research output is not available in the IDRC Digital Library or by request from the IDRC Library. / Compte tenu des restrictions relatives au droit d'auteur, le texte intégral de cet extrant de recherche n'est pas accessible dans la Bibliothèque numérique du CRDI, et il n'est pas possible d'en faire la demande à la Bibliothéque du CRDI.en
idrc.project.componentnumber104519010
idrc.project.number104519
idrc.project.titleInternational Research Chairs Initiative (IRCI)en
idrc.rims.adhocgroupIDRC SUPPORTEDen

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IDRC Research Results / Résultats de recherches du CRDI
2010-2019 / Années 2010-2019
Modelling and controlling infectious diseases / Se servir de la modélisation pour lutter contre les maladies infectieuses