Puerta-Guardo, HenryBiering, Scott B.Harris, EvaPavia-Ruz, NormaVázquez-Prokopec, Gonzalo2021-04-262021-04-262020-09-23978-1-78985-649-1http://hdl.handle.net/10625/59929Two part articleThis chapter details the interplay between distinct host adaptive immune responses and viral factors that together contribute to the development of the dengue virus (DENV) pathogenesis and severe disease. As Part II, it addresses: the multifactorial immunopathogenic process of DENV infection from the perspective of the pre-existing serotype cross-reactive antibodies; the hyperactivation of DENV infected immune cells (monocytes, mast cells) leading to increased cytokine production; the role of T cell responses; the activation of complement pathways; and the new pathogenic roles of the secreted NS1 of DENV that may act together to occasionally cause severe dengue manifestations.application/pdfenDENGUEMOSQUITO-BORNE DISEASESIMMUNOLOGYPATHOGENESISDISEASE CONTROLEPIDEMIOLOGYVACCINESARBOVIRUSLATIN AMERICAGLOBAL SOUTHBook Chapter