InnoVet-AMR: Innovative Veterinary Solutions for Antimicrobial Resistance / InnoVet-AMR : Solutions vétérinaires innovatrices pour la résistance aux antimicrobiens

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https://hdl.handle.net/10625/59812

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    Practical pathways to integrating gender and equity considerations in antimicrobial resistance research
    (2023) Lynch, Ingrid; Middleton, Lyn; Naemiratch, Bhensri; Fluks, Lorenza; Sobane, Konosoang
    Antimicrobial resistance (AMR) has become a major global concern, threatening human and animal health, food security, and food safety. Yet, the burden of AMR is not distributed equally, with the harmful impacts disproportionately felt by people living in LMICs where social, structural, and systemic challenges are contributing to the growing burden of AMR. Moreover, gender inequality and various forms of marginalization mean that women and vulnerable groups are particularly affected. This document is a flexible resource to help researchers incorporate gender and equity considerations into their studies. The primary focus of the document is on gender dimensions and not sex. The intended users are researchers conducting AMR innovation development and intervention implementation research in LMICs.
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    Infection of porcine small intestinal enteroids with human and pig rotavirus A strains reveals contrasting roles for histo-blood group antigens and terminal sialic acids
    (2021-01-29) Guo, Yusheng; Adriana Candelero-Rueda, Rosario; Saifid, Linda Jean; Vlasova, Anastasia Nickolaevna; Arias, Carlos F.; Hanson, Juliette; Lee, Marcia V; Wood, Ronna S; Kick, Maryssa K; Liu, Mingde
    The study established a porcine crypt-derived 3D intestinal enteroids (PIEs) culture system which contains all intestinal epithelial cells identified in vivo and represents a unique physiologically functional model to study RV-glycan interactions in vitro. Rotaviruses (RVs) are a leading cause of acute viral gastroenteritis in young children and livestock worldwide. Findings from the research indicate that targeting individual glycans for development of therapeutics may not yield uniform results for various RV strains. PIEs can serve as a model to study pathogen-glycan interactions and suggest that genetically distinct RVs have evolved diverse mechanisms of cell attachment and/or entry.