New pattern-based method for identifying recent HIV-1 infections from the viral env sequence

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IDL-51441.pdf (527.38 KB)

Date

2012

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Springerlink

Abstract

The study investigates a pattern-based method for measuring intra-patient viral genetic diversity for determination of recent infections and estimation of population incidence. Pattern-based diversities of recent infections are significantly lower than that of chronic ones. With larger window periods varying from 200 to 350 days, a higher accuracy (90%95%) not affected by advanced disease nor antiretroviral therapy (ART) treatment could be obtained. The pattern-based genetic method is supplementary to existing serology-based assays, both suitable for use in low and high epidemic regions respectively. The envelope (env) gene of HIV/SIV is the most variable of viral genes.

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Keywords

EPIDEMIOLOGY, ANTIRETROVIRAL THERAPY, HIV/AIDS, GENETICS, ENV GENE, EPIDEMIOLOGY, DISEASE MONITORING, ANTIBODIES, MATHEMATICAL MODELS, CHINA, GLOBAL

Citation

Jing Yang, XiaYu Xia, Xiang He, SenLin Yang, YuHua Ruan, QuanBi Zhao, et al. (2012). A new pattern-based method for identifying recent HIV-1 infections from the viral env sequence. Science China Life Sciences, 55(4), 328-335.doi:10.1007/s11427-012-4312-0

URI

http://hdl.handle.net/10625/51441

DOI

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IDRC Research Results / Résultats de recherches du CRDI
2010-2019 / Années 2010-2019
Modelling and controlling infectious diseases / Se servir de la modélisation pour lutter contre les maladies infectieuses