Processing and analysis of ChIP-seq data [Chinese language]

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IDL-51229.pdf (727.53 KB)

Date

2012

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Abstract

The next-generation sequencing coupled with chromatin immunoprecipitation (ChIP-seq) is becoming a key technology for the study of transcriptional regulation in the context of functional genomics. Due to the overwhelming amount of data generated from ChIP-seq experiments, the ChIP-seq data processing brings many new challenges in the field of bioinformatics. Considering the development of data processing skills largely behind that of the ChIP-seq experiment techniques, it is urgent to give a review on the ChIP-seq data processing for more and more oncoming researchers to build or improve algorithms. This paper provides a brief overview of the ChIP-seq data processing, highlighting the main prob-lems and methods in detail, to allow scientists to understand rapidly and deeply.

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Keywords

NEXT GENERATION SEQUENCING, CHIP-SEQ, DATA PROCESS, TRANSCRIPTION REGULATION, EPIGENETICS, GENOMICS, BIOINFORMATICS

Citation

S Gao Shan, Zhang Ning, Li Bo, Xu Shuo, Ye Yan-Bo, & Ruan Ji-Shou (2012). Processing and analysis of ChIP-seq data. HEREDITAS (Beijing), 34(6), 773-783.doi:10.3724/SP.J.1005.2012.00773

URI

http://hdl.handle.net/10625/51229
 http://www.chinagene.cn/Jwk_yc/EN/abstract/abstract20838.shtml

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IDRC Research Results / Résultats de recherches du CRDI
2010-2019 / Années 2010-2019
Modelling and controlling infectious diseases / Se servir de la modélisation pour lutter contre les maladies infectieuses