Biomarkers of selenium status in the Amazonian context : blood, urine and sequential hair segments

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dc.contributor.author Lemire, Melanie
dc.contributor.author Mergler, Donna
dc.contributor.author Huel, Guy
dc.contributor.author Passos, Carlos J.S.
dc.contributor.author Fillion, Myriam
dc.date.accessioned 2013-03-12T14:31:23Z
dc.date.available 2013-03-12T14:31:23Z
dc.date.copyright 2009
dc.date.issued 2009
dc.identifier.citation Lemire, M., Mergler, D., Huel, G., Passos, C.J.S., Fillion, M., Philibert, A., et al. (2009). Biomarkers of selenium status in the amazonian context: Blood, urine and sequential hair segments. Journal of Exposure Science and Environmental Epidemiology, 19, 213-222.doi:10.1038/jes.2008.14 en
dc.identifier.issn 1559-0631
dc.identifier.uri http://hdl.handle.net/10625/50842
dc.description.abstract Selenium (Se) is an essential element and deficit or excess of dietary Se is associated with health disorders. Relatively elevated Se levels have been reported in the Brazilian Amazon, where there are also important annual variations in the availability of different foods. The present study was conducted among six riparian communities of the Tapajo´ s River to evaluate seasonal variations in blood and sequential hair cm Se concentrations, and to examine the relationships between Se in blood and hair, and blood and urine. Two cross-sectional studies were conducted, at the descending water (DWS, n¼259) and the rising water (RWS, n¼137) seasons, with repeated measures for a subgroup (n¼112). Blood Se (B-Se), hair Se (H-Se) and urine Se (U-Se) were determined. Match-paired analyses were used for seasonal comparisons and the method of best fit was used to describe the relationships between biomarkers. B-Se levels presented a very large range (142–2447 mg/l) with no overall seasonal variation (median 284 and 292 mg/l, respectively). Sequential analysis of 13 cm hair strands showed significant variations over time: Se concentrations at the DWS were significantly lower compared with the rising water season (medians: 0.7 and 0.9 mg/g; ranges: 0.2–4.3 mg/g and 0.2–5.4 mg/g, respectively). At both seasons, the relationships between B-Se and H-Se were linear and highly significant (r2¼67.9 and 63.6, respectively), while the relationship between B-Se and U-Se was best described by a sigmoid curve. Gender, age, education and smoking did not influence Se status or biomarker relationships. Variations in H-Se suggest that there may be seasonal availability of Se sources in local food. For populations presenting a large range and/or elevated Se exposure, sequential analyses of H-Se may provide a good reflection of variations in Se status. en
dc.format Text en
dc.format.extent 1 digital file (p. 213-222) en
dc.format.mimetype Application/pdf
dc.language.iso en
dc.publisher Nature Publishing Group, Macmillan Publishers en
dc.subject BRAZILIAN AMAZON en
dc.subject EXPOSURE ASSESSMENT en
dc.subject SE STATUS en
dc.subject SEASONAL VARIATIONS en
dc.subject SEQUENTIAL HAIR en
dc.subject URINE en
dc.subject WHOLE BLOOD en
dc.subject SELENIUM en
dc.title Biomarkers of selenium status in the Amazonian context : blood, urine and sequential hair segments en
dc.type Journal Article (peer-reviewed) en
idrc.project.number 101416
idrc.project.title Mercury Exposure and Ecosystem Health in the Amazon (CARUSO) - Phase III en
idrc.copyright.holder Nature Publishing Group
idrc.dspace.access IDRC Only en
idrc.rims.adhocgroup IDRC SUPPORTED en
idrc.noaccess Due to copyright restrictions the full text of this research output is not available in the IDRC Digital Library or by request from the IDRC Library. / Compte tenu des restrictions relatives au droit d'auteur, le texte intégral de cet extrant de recherche n'est pas accessible dans la Bibliothèque numérique du CRDI, et il n'est pas possible d'en faire la demande à la Bibliothéque du CRDI. en


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