Analysis of HA gene’s variation and evolution in some avian influenza viruses from China [Chinese language]
Date
2008
Authors
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Publisher
Institute of Zoology (IOZ), Chinese Academy of Sciences (CAS)
Abstract
After collecting the HA gene sequences of 42 strains of avian influenza viruses(AIV) H5N1 isolated from human (Homo sapiens), poultry and wild birds by searching the GenBank of NCBI, we analyzed the transformation of the amino acid residues at key sites and constructed the phylogenetic tree using DNAStar and compared the homology and evolutionary relationship of these HA genes. The results suggest that HA genes of these AIV H5N1 viruses varies persistently at different rates. Within the same area or neighboring areas in China, the nucleotides are more homologous in the same year or between the continuous two years, indicating that some human AIV diseases may have been caused by the H5N1 viruses infection from poultry. And more researches concerning the role of wild birds are needed.
Description
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Journal Article (peer-reviewed)
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Keywords
AVIAN INFLUENZA H5N1, HA GENE, VARIATION, INFLUENZA IN BIRDS, ZOONOTIC DISEASES, GENETIC VARIATION, INFLUENZA A VIRUS, H5N1 SUBTYPE
Citation
Zhang Ji-Rong, & Lei Fu-Min (2008). Analysis of HA Gene’s Variation and Evolution in Some Avian Influenza Viruses from China. Chinese Journal of Zoology, 43(6): 10-16.